Interpolated model-matrix optoacoustic tomography of the mouse brain

source: © 2011 Applied Physics Letters

Neuroscience investigations may significantly benefit from the availability of accurate imaging methods of brain parameters in small animals. In this letter, we investigate the imaging performance of the recently introduced interpolated model-matrix inversion (IMMI), in quantitative optoacoustic imaging of the mouse head. We compare the findings of the method against back-projection inversion methods that have more commonly been considered. We find that cross-sectional images of the mouse head accurately match anatomical structures seen on cryosliced head images serving as the gold standard. Moreover, superior imaging performance is found for IMMI compared to previously reported optoacoustic imaging of the mouse head.  [Read more…]

Fig 2.Several cross-sectional slices of the head region of a mouse back projection based reconstructions of (a) head region, (b) lower part of the head, (c) and (d) corresponding IMMI reconstructions, (e) and (f) corresponding IMMI high-pass filtered images, and (g) and (h) cryoslices. Anatomical structure: 1, 3, 4, 6—eye sockets 2, 5, 7, 8—blood vessels.

Thomas Jetzfellnera, Amir Rosenthal, K.-H. Englmeier, Alexander Dima, Miguel Ángel Araque Caballero, Daniel Razansky, and Vasilis Ntziachristos, “Interpolated model-matrix optoacoustic tomography of the mouse brain,” Appl. Phys. Lett. 98, 163701 (2011)