Performance of iterative optoacoustic tomography with experimental data

source: © 2009 Applied Physics Letters

In this letter we experimentally demonstrate the sensitivity and overall performance of iterative correction for light attenuation in optoacoustic tomography as a function of number of iterations and accuracy of the tissue optical properties estimations. Experimental optoacoustic data were obtained by circularly illuminating a tissue-mimicking phantom with a high intensity pulsed near infrared laser and measuring the subsequent acoustic waves using a broadband acoustic hydrophone. We showcase an improvement in image fidelity and quantification due to the iterative inversion but find the method sensitive to the background optical properties and of a diverging behavior when increasing the number of iterations.  [Read more…]

Fig. 2 The reconstruction error of the algorithm as a function of iteration for different assumed reduced scattering coefficient values. In all cases μa=20 cm−1 and σ=0.001. The quality measures showed assumed (a) the standard deviation within the insertion and (b) a root-mean-square error estimate given in Eq. (4).

Thomas Jetzfellnera, Daniel Razansky, Amir Rosenthal, Ralf Schulz, K.-H. Englmeier, and Vasilis Ntziachristos, “Performance of iterative optoacoustic tomography with experimental data,” Appl. Phys. Lett. 95, 013703 (2009)