source:© 2017 Optical Society of America
To enable quantitative molecular and morphological readings in vivo, a near-infrared fluorescence (NIRF)-IVUS catheter and a novel correction algorithm were engineered. Hybrid imaging was validated in atherosclerotic rabbit model in vivo.[Read More…]
Fig 2. In vivo cNIRF-IVUS imaging of inflammation in atherosclerosis.cNIRF-IVUS in vivo imaging of atherosclerosis-related inflammation inside a rabbit aorta revealed two areas (12-30mm and 38-50mm at Fig. 2a, c) of elevated NIR fluorescence activity with a 7mm lower NIRF signal in between. The same fluorescence distribution was observed on the ex vivo FRI image (Fig. 2b). Representative cross-sectional cNIRF-IVUS images at pullback position 1 and 2 (at Fig. 2a) are shown in Fig. 2d and e.