Quantitative Intravascular Fluorescence-Ultrasound Imaging In Vivo

source:© 2017 Optical Society of America

To enable quantitative molecular and morphological readings in vivo, a near-infrared fluorescence (NIRF)-IVUS catheter and a novel correction algorithm were engineered. Hybrid imaging was validated in atherosclerotic rabbit model in vivo.[Read More…]

Fig 2. In vivo cNIRF-IVUS imaging of inflammation in atherosclerosis.cNIRF-IVUS in vivo imaging of atherosclerosis-related inflammation inside a rabbit aorta revealed two areas (12-30mm and 38-50mm at Fig. 2a, c) of elevated NIR fluorescence activity with a 7mm lower NIRF signal in between. The same fluorescence distribution was observed on the ex vivo FRI image (Fig. 2b). Representative cross-sectional cNIRF-IVUS images at pullback position 1 and 2 (at Fig. 2a) are shown in Fig. 2d and e.

D. Bozhko, E. A. Osborn, A. Rosenthal, J. W. H. Verjans, T. Hara, J. R. McCarthy, S. Kellnberger, G. Wissmeyer, A. Mauskapf, A. F. Stein, F. A. Jaffer, and V. Ntziachristos, “Quantitative Intravascular Fluorescence-Ultrasound Imaging In Vivo,” in Optics in the Life Sciences Congress, OSA Technical Digest (online) (Optical Society of America, 2017), paper OmM2D.3.