Ultrasound Detection Using Acoustic Apertures

source: © 2018 IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

Ultrasound detection is commonly performed by piezoelectric transducers that are optimized for a specific application. Since the piezoelectric technology is not configurable, transducers designed for one application may not be compatible with other applications. In addition, some designs of ultrasound transducers may be difficult to implement owing to production constraints. In this paper, we propose a simple, low-cost method to reconfigure the geometry of ultrasound transducers. The technique is based on using apertures in thin sheets of acoustic blockers. We experimentally demonstrate this method for an ultrasound transducer with a central frequency of 1 MHz and show that it can emulate detectors of various sizes. An added advantage of this technique is its capability to achieve semi-isotropic detection sensitivity due to diffraction when the aperture size is comparable to the acoustic wavelength even when the angular sensitivity of the transducer is inherently limited.[Read More…]

Fig. 1 (a) Side view illustration of the detection scheme used in this paper. An ultrasound blocking mask with an aperture is placed in front of a large-area ultrasound receiver, resulting in an emulated detector whose detection characteristics depend on the aperture geometry. (b) Illustration of the experimental setup in which the emulated detector was used to characterize the 2-D diffraction map from an ultrasound transmitter. (c) Illustration of the setup used for characterizing the angular sensitivity of the emulated detector. (b) and (c) Transmitter was scanned in the xy plane while keeping the same z value for the transmitter, the receiver, and the aperture mask centers.

E Hahamovich, A Rosenthal, “Ultrasound Detection Using Acoustic Apertures”,in IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ( Volume: 65 , Issue: 1 , Jan. 2018 )

Modeling the sensitivity dependence of silicon-photonics-based ultrasound detectors

source: © 2017 Optical Society of America

With recent advances in optical technology, interferometric sensing has grown into a highly versatile approach for ultrasound detection, with many interferometric detectors relying on optical waveguides to achieve high levels of sensitivity and miniaturization. In this Letter, we establish a practical model for assessing the sensitivity of silicon-photonics waveguides to acoustic waves. The analysis is performed for different polarizations, waveguide dimensions, and acoustic wave types. Our model was validated experimentally in the acoustic frequency band of 1–13 MHz by measuring the sensitivities of the two polarization modes in a silicon strip waveguide. Both the experimental results and theoretical prediction show that the transverse-magnetic polarization achieves a higher sensitivity and suppression of surface acoustic waves compared to the transverse-electric polarization for the geometries studied. [Read More…]

Fig. 2. Numerical calculation of normalized sensitivity ?? as a function of the waveguide width (??) and height (??) and polarization for (a), (b) the longitudinal acoustic wave in normal incidence and (c), (d) SAWs created in oblique incidence.

Shai Tsesses, Daniel Aronovich, Assaf Grinberg, Evgeny Hahamovich, and Amir Rosenthal “Modeling the sensitivity dependence of silicon-photonics-based ultrasound detectors”, Optics Letters Vol. 42, Issue 24, pp. 5262-5265 (2017)

Fiber interferometer for hybrid optical and optoacoustic intravital microscopy

source: © 2017 Optical Society of America

The addition of optoacoustic sensing to optical microscopy may supplement fluorescence contrast with label-free measurements of optical absorption, enhancing biological observation. However, the physical dimensions of many optoacoustic systems have restricted the implementation of hybrid optical and optoacoustic (O2A) microscopy to imaging thin samples in transmission mode or to ex-vivo investigations. Here we describe a miniaturized optoacoustic sensor, based on a ?-phase-shifted fiber Bragg grating embedded in an acoustic cavity, which is virtually invisible to the optical path and can be seamlessly integrated into any conventional optical microscope. The new sensor enables, for the first time to our knowledge, entirely optical O2A intravital microscopy in epi-illumination mode, demonstrated by label-free optoacoustic and second-harmonic generation images of a mouse abdomen and ear. Our technique greatly simplifies the integration of acoustic detection in standard microscopes and could therefore make optoacoustic microscopy more accessible to the biomedical community. [Read More…]

Fig. 5. Schematic depiction of the O2A microscopy setup: A standard inverted microscope with laser sources for optoacoustic and non-linear optical imaging is combined with galvanometric mirrors for fast laser raster scanning. The sensor is mounted on the microscope objective, with a tunable CW laser coupled to the embedded ?-FBG. The inset shows the 3D printed platform supporting an anesthetized mouse and mounted on a ??? positioning stage. DM, dichroic mirror; BP, bandpass filter; PH, pinhole; ND, neutral density filter; BS, beam splitter; PMT, photomultiplier tube; OA, optoacoustic; DAQ, data acquisition card.

Authors: Rami Shnaiderman, Georg Wissmeyer, Markus Seeger, Dominik Soliman, Hector Estrada, Daniel Razansky, Amir Rosenthal, and Vasilis Ntziachristos, “Fiber interferometer for hybrid optical and optoacoustic intravital microscopy,” Optica 4, 1180-1187 (2017)

All-optical optoacoustic microscope based on wideband pulse interferometry

Microscopy scans of (a)–(c) a mouse ear and (d)–(f) a zebrafish larva ex vivo.

source:© 2016 Optical Society of America

Optical and optoacoustic (photoacoustic) microscopy have been recently joined in hybrid implementations that resolve extended tissue contrast compared to each modality alone. Nevertheless, the application of the hybrid technique is limited by the requirement to combine an optical objective with ultrasound detection collecting signal from the same micro-volume. We present an all-optical optoacoustic microscope based on a pi-phase-shifted fiber Bragg grating (?-FBG) with coherence-restored pulsed interferometry (CRPI) used as the interrogation method. The sensor offers an ultra-small footprint and achieved higher sensitivity over piezoelectric transducers of similar size. We characterize the spectral bandwidth of the ultrasound detector and interrogate the imaging performance on phantoms and tissues. We show the first optoacoustic images of biological specimen recorded with ?-FBG sensors. We discuss the potential uses of ?-FBG sensors based on CRPI.
[Read More…]

Fig. 1. Schematic of the all-optical optoacoustic microscope. ND, neutral density filter; L, lens; M, mirror; PH, pinhole; xyz, motorized translation stages; DAQ, data acquisition system; EDFA, erbium-doped optical amplifier; PZ, piezoelectric fiber stretcher.

G. Wissmeyer, D. Soliman, R. Shnaiderman, A. Rosenthal, and V. Ntziachristos, “All-optical optoacoustic microscope based on wideband pulse interferometry,” Opt. Lett. Vol. 41, pp. 1953-1956 (2016).

Magnetoacoustic sensing of magnetic nanoparticles

Magnetic fluid heating and magnetoacoustic signal induction

source: © 2016 Physical Review Letters

The interaction of magnetic nanoparticles and electromagnetic fields can be determined through electrical signal induction in coils due to magnetization. However, the direct measurement of instant electromagnetic energy absorption by magnetic nanoparticles, as it relates to particle characterization or magnetic hyperthermia studies, has not been possible so far. We introduce the theory of magnetoacoustics, predicting the existence of second harmonic pressure waves from magnetic nanoparticles due to energy absorption from continuously modulated alternating magnetic fields. We then describe the first magnetoacoustic system reported, based on a fiber-interferometer pressure detector, necessary for avoiding electric interference. The magnetoacoustic system confirmed the existence of previously unobserved second harmonic magnetoacoustic responses from solids, magnetic nanoparticles, and nanoparticle-loaded cells, exposed to continuous wave magnetic fields at different frequencies. We discuss how magnetoacoustic signals can be employed as a nanoparticle or magnetic field sensor for biomedical and environmental applications.
[Read More…]

Figure 1
Concept of magnetoacoustic signal induction. (a) Components of the magnetoacoustic setup. Power supply (PS), modulator (M), water chiller (W), driver (D). (b) Magnetoacoustic sensing using a PZT transducer. The sample comprises a steel rod located within the coil. (c) rf-free magnetoacoustic sensing employing a fiber-Bragg-based interferometric ultrasound sensor in a horizontally arranged solenoid (water tank not displayed). The optical sensor comprises optical filters (F), an erbium-doped fiber amplifier (EFDA), a 99/1optical splitter (S), a demodulator (Demod), and the π-shifted FBG sensing unit. (d) Magnetoacoustic sensing of a steel rod specimen using PZT based ultrasound detection. rf interference due to the nonlinearity of the rf amplifier (blue dotted line) and experimental confirmation of the second harmonic magnetoacoustic signal (red line) induced in conducting material at f_MA=2f_rf. Inset shows the quadratic increase of detected magnetoacoustic signal (red crosses) as a function of the linearly rising B field compared to the expected theory (dashed black curve) and a linear relationship (dotted green line).

Kellnberger, A. Rosenthal, A. Myklatun, G. G. Westmeyer, G. Sergiadis, and V. Ntziachristos, ” Magnetoacoustic sensing of magnetic nanoparticles,” Phys. Rev. Lett., Vol. 116, 108103 (2016).